Though Half Life is a Windows based PC game, a version for Play station is also available. The game was developed by ex employees of Microsoft and first released in 1997. It is a role playing game where the gamers become Dr Gordon Freeman who is a physicist and whose experiments on new technologies have gone wrong and he must somehow escape from his research facility that is underground and also secret. The peak plasma concentration of a drug after administration.Half Life is a popular video game that is played by millions of sci-fi games crazy people around the world. For a more detailed description see Pharmacokinetics § Multi-compartmental models. The longer half-life is called the terminal half-life and the half-life of the largest component is called the dominant half-life.
SHALLOW part of curve -> ultimate excretion of drug, which is dependent on the release of the drug from tissue compartments into the blood. STEEP (initial) part of curve -> initial distribution of the drug in the body. Many drugs follow a biphasic elimination curve - first a steep slope then a shallow slope:
For this reason, drugs with a long half-life (e.g., amiodarone, elimination t ½ of about 58 days) are usually started with a loading dose to achieve their desired clinical effect more quickly. So, for example, digoxin has a half-life (or t ½) of 24–36 h this means that a change in the dose will take the best part of a week to take full effect.
In clinical practice, this means that it takes 4 to 5 times the half-life for a drug's serum concentration to reach steady state after regular dosing is started, stopped, or the dose changed. Time for a medication to halve its concentration in blood plasmaīiological half-life (also known as elimination half-life, pharmacologic half-life) of a biological substance such as medication is the time it takes from its maximum concentration ( C max) to half of its maximum concentration in the blood plasma, and is denoted by the abbreviation t 1 2
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